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Model AD Explorer — Next-generation models of Alzheimer's Disease

The Model AD Explorer is a publicly accessible scentific application developed and maintained by Sage Bionetworks, a 501(c)(3) nonprofit biomedical research organization, with funding from the National Institute on Aging (NIA). The Model AD Explorer is part of the broader AD Knowledge Portal ecosystem at adknowledgeportal.org.

About the Model AD Explorer

The Model AD Explorer hosts summaries of phenotypic data for in vivo models of Alzheimer's Disease (AD) to enable researchers to select the most appropriate model to use for their research. The Model AD Explorer was initially developed with support of the NIA's Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease (MODEL-AD) Consortium.

About the AD Knowledge Portal

The AD Knowledge Portal (adknowledgeportal.org) is an open-access database developed by Sage Bionetworks that disseminates data, tools, and analytical results generated by multiple National Institute on Aging-funded programs focused on aging, dementia, and Alzheimer's disease. The portal hosts data and resources generated across 100+ grant projects in 10+ NIA-supported programs and centers, including multi-omic data from human samples and experimental model systems.

The portal was developed as part of the Accelerating Medicines Partnership in Alzheimer's Disease (AMP-AD) program between the NIH and several nonprofit organizations and pharmaceutical companies, and has since expanded to include data from additional NIA-funded consortia.

What You Can Do on the Model AD Explorer

Explore detailed phenotypic characterization results for 15+ AD mouse models.
Compare genome-wide differential RNA expression results for the available mouse models.
See how changes in mouse model gene expression correlate with changes in gene expression in human AD patients.
View pathology and biomarker evidence for the available mouse models.
Search for mouse models by name, JAX ID, RRID, or by modified gene.
Find results for additional mouse models as they become available.
See results for other AD model organisms developed by the NIA-funded Marmo-AD and MPS-AD consortia as they become available.

Nonprofit Identity

Sage Bionetworks
A 501(c)(3) nonprofit research organization
EIN: 26-4489946
Seattle, Washington, USA
sagebionetworks.org
Trust Center — Terms of Service, Privacy Policy, financial statements, and governance documents

Learn More

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Find the right model for your research

Explore the phenotypic characterization of next-generation models of Alzheimer's Disease (AD) developed by the MODEL-AD consortium and MARMO-AD.

Mouse Models

Marmoset Models

Mouse Model Search

Find a mouse model by name, JAX ID, or RRID to explore Biomarker data, Pathology results, and detailed model information.

Institutions

5+

Genes

20K+

Models

15+

How it Works

Our Methodology

MODEL-AD comprises two research centers with complementary approaches to generating new mouse models that more faithfully recapitulate features of Alzheimer's disease in humans. Mouse models are phenotyped using standardized neuropathology, 'omics, and behavioral measures.